Dysplastic alterations of peripheral blood (PB) and bone marrow (BM) are still fundamental for the diagnosis and classification of this group of diseases. ![]() So far, there is no single reliable biological or genetic marker for diagnosis. Introduction Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell (HSC) clonal diseases resulting from a sequence of acquired genetic alterations with the formation of an anomalous and genetically unstable clone or clones, with potential to evolve to acute myeloid leukemia. ![]() What examinations are needed to confirm the diagnosis of myelodysplastic syndromes? Thus, 38 studies were found and selected to answer the clinical question (. ![]() PICO system Using the PICO system, the P corresponds to patients with suspected myelodysplastic syndrome, I to the indication of examinations, and O to the outcomes (diagnosis). Part 1: Myelodysplastic Syndromes – Laboratory workup to confirm diagnosis Objective This article presents the guidelines on the examinations that are needed to confirm the diagnosis of myelodysplastic syndromes.
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